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In contrast, hydroxamates (311) usually have a wide roptimal pH range from 4 to 9, and described optimal chelation conditions for alpha-hydroxycarboxylates usually lie within the pH of 5–7 ( Figure 4 Generally, siderophore production is downregulated at low pH and upregulated with high pH (312)

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For patients with diminished ovarian reserve, a higher dosage of 600 mg/day over a period of 60 days has been shown to be more effective in enhancing ovarian response to gonadotropins