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In vitro and in vivo studies suggest that quercetin can attenuate oxidative stress by enhancing the activity of antioxidant enzymes such as SOD and CAT, which are often dysregulated in RA [100] Another promising polyphenol is epigallocatechin gallate (EGCG), the primary catechin found in green tea

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The 5′ adenosine monophosphate kinase (AMPK) is pivotal to responding to many metabolic scenarios, largely to switch to a more catabolic state and mobilise internal fuel stores when cellular energy is low