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The de novo thymidylate (dTMP) biosynthesis pathway involves three enzymes: dihydrofolate reductase (DHFR), serine hydroxymethyltransferase (SHMT), and thymidylate synthase (TYMS) ( Figure 3 )

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GABA not only decreased liver damage caused by a toxic reagent but also reduced liver ischemia and reperfusion injury by modulating the hepatic insulin signaling and gluconeogenesis pathways [18] (Figure 2)