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This activates NF-κB to trigger neuroinflammation, ultimately exacerbating SNpc dopaminergic neuron apoptosis in PD (162)

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When reduced forms of coenzyme Q 10 (CoQ 10 H 2 ), vitamin C (ascorbate), or glutathione (GSH) reduce oxidized α-tocopherol (α-TO•), they themselves become oxidized (ubisemiquinone, dehydroascorbate, or GSSG)