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First-party SNTs funded with the beneficiary’s assets must generally be established before the individual reaches the age of 65, and third-party trusts funded by non-beneficiary assets do not carry an age restriction

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The S2 subsite is also sufficiently deep to accommodate a larger side chain and is lined by the side chains of Lys208, Arg220 and Thr222 from the N-terminal barrel and Phe673 from the C-terminal barrel