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However, it should be noted that these findings provide indirect evidence for venous recanalization, as they are based primarily on angiogenesis markers rather than on direct functional assessment of vessel patency

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373 Additionally, IDO inhibition, which targets metabolic immunosuppression, has shown synergy with anti-PD-L1 and anti-CTLA-4 therapies in preclinical GBM models, resulting in 100% long-term survival