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Their benefit in HS is mediated through effects on inflammatory pathways (affecting the cytokines tumour necrosis Factor α and Interleukin 17, respectively) ​24​

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In the morning (9.00 – 10.00 am) of experimental day 1, chow pellets were removed from food hoppers, and mice were ICV-injected with 2 µL of either vehicle (DSMO 5% v/v in aCSF) or PF-5190457 (100 pmol/mouse)