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M9a + sh EPAS1 cells upregulate HIF-1α-BNIP3/NIX-mediated mitophagy and suppress mtDNA-mediated inflammation under hypoxia condition Hypoxia-induced mitophagy is typically mediated by BNIP3/NIX and regulated by HIF-1α [28], so we first excluded the involvement of PINK1/PARKIN-mediated mitophagy in Tibetan hypoxia adaptation (Supplementary Fig