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In order to compute the frequency response, we assessed the effect of endocytic downregulation and desensitization on the system response to non-negative sinusoidal inputs with a peak value A nM/min and frequency ω = 2 π/ λ radians/min, i.e., the ligand entry rate was of the form f ( t ) = ( A /2) [1 - cos( ωt )] (see Methods section)

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The peacocks did not live up to Noble’s hopes