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62 However, BCG has been injected into the pleural cavity or the bladder of patients with inoperable cancer of these regions in the hope that it would have a non-specific adjuvant effect on the immune reaction to the cancer and, as with its use in preventing tuberculosis, there are rare instances of the bacillus being disseminated widely throughout the body.63, 64 The relationship of immunity to hypersensitivity in tuberculosis The rapid translocation of tubercle bacilli to the regional lymph nodes, and perhaps beyond, on first infection, is less likely in postprimary tuberculosis, indicating some degree of acquired immunity, while the development of caseation at a time when cellular immune mechanisms may be expected to take effect suggests that hypersensitivity accompanies the immunity