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Future studies are warranted to elucidate whether these products influence bone remodeling through interference with chemokine pathways, which could offer additional therapeutic leverage in the treatment of bone resorptive disorders

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For mechanisms, single-cell spatial transcriptomics from human postsurgical TBI samples should map cell death interactions across primary injury zones (necroptosis-dominant), secondary injury zones (pyroptosis–ferroptosis interaction), and unaffected regions