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It is of interest that the alarmin IL-33 [270,305,359] stimulates MCs, significantly increasing the ability of SP to stimulate the release of VEGF [287,360], IL-31 [361], TNF-α, and IL-1β [304], as well as CCL2 and CCXL8 [362] and other newly synthesized mediators from human MCs [270]

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623 The sVEGFR1:PlGF ratio serves as a predictive marker for PE risk