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Preclinical studies indicate that systemic glutamine deprivation may induce muscle atrophy and intestinal mucosal damage (7), while high-dose administration of the ammonia scavenger sodium phenylbutyrate carries a risk of neurotoxicity (128)

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Consequently, the scarcity of human-relevant preclinical models significantly contributes to high therapeutic failure rates resulting in fewer effective drugs for treating COPD patients and ultimately to rising healthcare costs 22