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Diabetes endpoints were defined according to the recommendations of the World Health Organization, and the inclusion and exclusion criteria were based on the International Classification of Diseases, 3 particularly the 9th or 10th edition (29)

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Cagrilintide is a single-mechanism amylin analog that activates amylin and calcitonin receptors to drive satiety signaling, while retatrutide is a triple receptor agonist that simultaneously stimulates GLP-1, GIP, and glucagon receptors