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See this journal : Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study, which includes the following statement: In 1969, Berchtold et al (1) reported evidence of vitamin B12 malabsorption in patients who had been treated with metformin for as little as 3 months

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Vitamin B12 supplementation was highly beneficial for young, rapidly-growing cattle to support high growth rates and immune function, Ms Krilich said