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Response: As outlined in the CY 2025 PFS final rule (89 FR 98291), after considering the data limitations of the proposed estimation methodology and public comments that highlighted related concerns and limitations of this approach, we did not finalize the proposed estimation methodology for the applicable period beginning on October 1, 2025

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Color:6

In rodent studies it has shown rapid antidepressant-like activity and, relevant to cognition, has been associated with increased markers of neurogenesis and synaptogenesis in the hippocampus, including effects linked to BDNF signaling