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Therefore, ischemic/reperfusion colitis (medication (BPC 157, L-NAME, L-arginine (alone/combined), saline, as a bath at the blood-deprived colon segment by two ligations of the left colic artery and vein) appears to be an additional illustrative complex example of distinctive NO-response patterns depending on the target [194]

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All the experiments were conducted according to a study protocol approved by the Institutional Ethics Committee of Kagawa University (Heisei 24–040) upon obtaining informed consent from all subjects