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In IBS, this equilibrium is disturbed, as dysbacteriosis, increased gut permeability, visceral hypersensitivity, and mucosal microinflammation are present

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This 80% increase, observed in third-trimester pregnant women was estimated to occur throughout the entire pregnancy.”[⁶⁰] This means **43% MORE of the toxic NAPQI metabolite is produced** during pregnancy compared to non-pregnant women

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