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In addition, a study found that young and mature animals, as well as obesity prone Osborne–Mendel rats, on a MR diet exhibited long-term increases in energy expenditure and uncoupling protein-1 (UCP-1) in both brown and white adipose tissue
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In addition, a variety of synthetic compounds with in vitro antioxidant activity have been developed to treat diseases, including recombinant SOD, catalase, nitroxyl radicals, iron ion chelators, deuterated PUFAs, thiols, and ROS-generating enzyme inhibitors