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Appendicular skeletal muscle exhibits an extrapulmonary phenotype, where under conditions of chronic energy deficiency and oxidative stress, mitochondrial abnormalities are more likely to be associated with apoptosis, mitophagy imbalance, and increased susceptibility to ferroptosis

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On the other hand, parvalbumin positive (PV + ) neurons displayed higher SOD2 immunoreactivity compared to parvalbumin negative (PV-) neurons in both the CA1 and the subiculum therefore, PV- and PV+ neurons were analyzed separately