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Subsequent STEP trials on diabetic patients (STEP 2), added-on therapy on intensive lifestyles (STEP 3), a study in Asian people (STEP 6), a comparison study with liraglutide (STEP 8), a study in adolescents (STEP TEENS), a study in persons with heart failure with preserved ejection fraction (STEP-HFpEF), and a study assessing cardiovascular outcome (SELECT-Semaglutide Effects on Heart Disease and Stroke in Patients with Overweight or Obesity trial) showed significant benefit of semaglutide for treatment of obesity and cardiovascular diseases [31-37]