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[41] provided evidence of a significant decrease in total vitamin B12 and haptocorrin levels after only 3 months of metformin use in older adults

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Vitamin B12 is released from its receptors and, after degradation by lysosomes, the IF-vitamin B12 complex is released from its receptor, IF is degraded in lysosomes and vitamin B12 enters the circulation via the multidrug resistance protein 1 (MDR1) transporter