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Key findings include: Decreased sensitivity of neuronal receptors to excitatory glutamate stimulation Attenuation of excitotoxic processes, which may protect neurons under ischemic or stress conditions NMDA interaction proposed as a primary CNS mechanism in multiple in vitro studies Potential role in reducing calcium-mediated neuronal damage during hypoxia GABAergic System Interactions – Inhibitory Neurotransmission Studies have documented DSIP’s enhancement of GABA-activated currents in hippocampal and cerebellar neuron preparations[2]

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However, when comparing these results, it is important to note that the inclusion criteria for PLE in foreign reports are CE [48,49,50,52,53], whereas those for PLE in Japanese reports include GISCL and gastrointestinal large cell lymphoma (GILCL) [47,51]