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Thus, the purpose of this review is to provide an overview of the medical effects and applications of NAC to human health based on current therapeutic evidence

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When melatonin receptors first appeared has not been thoroughly investigated but is surmised to have occurred during the Triassic Period (250 mya) (66), so the functions of melatonin (and its metabolites) prior to that time were receptor-independent, e.g., they functioned in the modulation of metabolic processes without an intervening receptor including as a direct ROS scavenger, etc

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