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Flow cytometry analysis of TVRTSAE peptide dose-response and cell binding SKOV3 were seeded at a density of 1 × 10 5 cells per well in a 96-well plate

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Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity