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Our structural studies indicate that CRBN makes concerted movements to accommodate the induced ENL interaction with a high degree of shape complementarity, which is congruent with emerging studies demonstrating that the CRBN surface is highly plastic and capable of accommodating diverse structural degrons 42,104,105,106
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doi: 10.1172/JCI8124 41 SoumelisVRechePAKanzlerHYuanWEdwardGHomeyBet al