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The findings highlight the possibility of identifying NNMT as a specific GSC phenotype and propose that NNMT is involved in maintaining GSC stemness ( NNMT expression contributes to DNA methylation by participating in nicotinate and methyl donor metabolism ( NNMT expression in the OVCAR3 cell line, increased the proportion of CD44-expressing cancer stem-like cells

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Primary testicular cell cultures, including isolated Sertoli cells and spermatogonial stem cells, provide tractable systems for investigating EED effects on specific cellular functions