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For wild-type nodules, the GSH:hGSH ratio was lowest in 1-week-old nodules, intermediate in 3-week-old nodules, and highest in 2-week-old nodules (Supplementary Table 2)

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However, one study reported that fentanyl causes an increase in production of reactive oxygen species in freshly isolated peripheral blood lymphocytes 118 , which arguably may involve a reduction in cellular reduced thiol levels