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Pantothenate kinase 2 interacts with PINK1 to regulate mitochondrial quality control via acetyl-CoA metabolism

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According to some research, melatonin has anti-inflammatory qualities and can decrease the release of pro-inflammatory factors, 70 but when melatonin is disrupted, its anti-inflammatory effects are diminished and intestinal neuroinflammation is worsened, which interferes with the ENS’s normal nerve conduction and impairs intestinal peristalsis, raising the risk of constipation