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Intravenous colchicine is strongly discouraged due to the risk of serious adverse events, including fatal toxicity, and is no longer FDA-approved in the United States.[111] The most common adverse effects are abdominal cramping and diarrhea.[109][112] In high-risk patient groups, colchicine dosing must be further reduced, often to a single 0.3 mg dose on the day of the flare with no repeat dosing for at least 3 to 7 days or longer

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The cochlea, particularly its metabolically active hair cells, spiral ganglion neurons, and the stria vascularis, is exceptionally rich in mitochondria, rendering it highly vulnerable to oxidative stress (Kishimoto-Urata et al., 2022