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The intrinsic ability of cancer cells to tolerate and recover from this DNA damage can stem from several pathways, including anti-apoptotic mechanisms, cell cycle arrest, DNA damage repair (DDR) and nucleotide metabolism, the oxidative/electrophilic stress response to free radicals, autophagy

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Also, individuals with COMT defects can be at higher risk for accumulating too much peroxynitrites which builds up in their bodies, causing stiffness and muscle pain or “brain fog” and cardiovascular problems