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Figure 4 6.1 Nanocapsules and MOFs Multilayer polymer nanocapsules are potential nanoparticles for the regulation of MDSCs, in which multilayer polymer nanocapsules encapsulating the chemokine CCL2 of mononuclear macrophage MDSCs and RNAi sequences shC/EBPβ and miR 142-3p that regulate the CCAAT/enhancer-binding protein β (C/EBPβ) pathway covered by polyarginine and hyaluronic acid layers can be RNAi transfected in MDSCs, down-regulate C/EBPα in spleen and tumor MDSCs thereby reversing the immunosuppressive phenotype and are potential nanoparticles for modulating MDSCs (119)