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Glutathione is a naturally occurring antioxidant that is found in, and used by, every cell in the body

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In the same cells, opioids have also been shown to induce the ubiquitination and degradation of regulator of G protein signaling 4 (RGS4), a protein that controls the duration of G protein signaling by acting as a GTPase accelerating protein (GAP) (Wang and Traynor, 2011)