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Senescent cells accumulate primarily at sites of vascular hypertrophy in pulmonary hypertension models [162] and contribute to the pathology through the recruitment of inflammatory cells by the SASP and by promoting vascular cell growth and migration [38,156]

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In 1891, it was found to be useful to treat malaria, thus making methylene blue "the first synthetic compound ever used as an antiseptic in clinical therapy and the first antiseptic dye to be used therapeutically," according to the authors of a Medicinal Research Reviews paper on the compound

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