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Current pharmacological strategies for UC primarily include 5-aminosalicylic acid (5-ASA), glucocorticoids, thiopurines, biological medications, and anti-cytokine therapies (Tsujii et al., 2022)

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Using a combination of X-ray crystallography and LO-NMR methods, we identified fragments binding in both the leucine and phenylalanine binding pockets of the TIN2 binding site, two sites crucial for TIN2 TBM engagement with TRF1 TRFH through the F-X-L-X-P motif 15

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