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393 It’s worth noting that compound heterozygous mutations in C10orf2 , which encodes the mitochondrial replicative helicase Twinkle, can also cause mtDNA depletion and present as Alpers-Huttenlocher syndrome

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Substituting refined sucrose with natural sweeteners, such as honey or fruit concentrates, can lower the glycemic load while improving microbial adaptability and fermentation performance [88,90]