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Gao Tan and colleagues have elucidated that pyroptosis promotes CD progression through GSDME cleavage [81]

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When PFK is inactive, the concentration of fructose-6-phosphate (F-6-P) increases, which in turn leads to increasing G-6-P levels, due to the existing balance of it with F-6-P, an equilibrium catalysed by PGI [142]