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In addition to causing damage to urothelial cells, ROS directly activate the NF-κB signaling pathway [193], which plays an important role in IC/BPS, as shown by recent transcriptome and single cell omics studies performed in the bladders of patients with IC/BPS [58, 182]

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Efficacy and safety of tranexamic acid 5% cream vs hydroquinone 4% cream in treating melasma: A split-face comparative clinical, histopathological, and antera 3D camera study