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Subsequent phase I clinical trials demonstrated a strong synergistic effect of lenvatinib in combination with the EGFR inhibitor gefitinib in advanced HCC with high expression of EGFR and refractory to lenvatinib mono-therapy, with 9 out of 30 cases achieving partial response (NCT04642547)
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[14] In carbon tetrachloride solutions DMSO functions as a Lewis base with a variety of Lewis acids such as I 2 , phenols, trimethyltin chloride, metalloporphyrins, and the dimer Rh 2 Cl 2 (CO) 4