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Abbreviations ABC ATP-binding cassette BSO L-buthionine ( S,R )-sulfoximine CFTR cystic fibrosis transmembrane conductance regulator EHBR Sprague Dawley Eisai hyperbilirubinuric rat, mutant rat strain that lacks Mrp2 activity GY Groningen Yellow rat, Wistar rat strain that lacks Mrp2 activity GSH reduced glutathione GS-NO S -nitrosoglutathione GSSG glutathione disulfide MDR1 multidrug resistance protein 1 MRP and Mrp multidrug resistance-associated protein OATP and Oatp organic anion transporting polypeptide TR- transport deficient rat, Wistar rat strain that lacks Mrp2 activity Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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