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Hyperglycemia results in the storage of metabolic substrates, causing the accumulation of glycolytic intermediates and the formation of mitochondrial ROS (mtROS) from the electron transport chain (ETC), ultimately inducing mitochondrial dysfunction and energy metabolism imbalance[112, 113]

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10.1016/j.matt.2020.05.017 192 Mac SweeneyR.McAuleyD