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The transcription of the gene is stimulated by CREB, phosphorylated after an increase in cAMP levels, and the subsequent activation of protein kinase A (PKA)

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Characteristics of Included Studies CLINICAL VALIDITY A total of 25 studies evaluated the risk of severe fluoropyrimidine-related toxicity in carriers of at least one of the DPYD variants under assessment and treated with a standard fluoropyrimidine dose, compared to wild-type patients

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