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It has been approved for clinical use in the therapy of angina pectoris [210, 211]

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137 Mitochondria produce ATP by generating a proton gradient (membrane potential) through the action of five ETC complexes, including complex 1 (NADH dehydrogenase), complex 2 (succinate dehydrogenase), complex 3 (cytochrome bc1 complex), complex 4 (cytochrome c oxidase), and ATP synthase, also known as complex 5