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41 Also, there are variations in the findings from various studies, and these may be due to variety of protocols for sampling and techniques for characterizing the microbial ecology – such as workflows for specimen storage and processing, lack of standardization of experimental protocols, different analysis methods, and the extent to which other confounding factors were considered – could account for the inconsistencies in the findings from the studies

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However, a functional assignment of these residues remains difficult because of the absence of structures with transition-state analogues that allow the discrimination between the glutathione moieties from the GSSR substrate or GSH (Fig