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In the acute GA model, luteolin inhibited the expressions of TLR2 and TLR4 mRNAs, reduced their protein expression levels, and ameliorated acute inflammation in GA by downregulating the TLR/MyD88/NF-κB signaling pathway, which in turn inhibited the expression of the downstream inflammatory factors IL-1β, IL-6, and TNF-α (175)

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Incidence and mortality of colorectal adenocarcinoma in persons with inflammatory bowel disease from 1998 to 2010