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4.2.1.2 Synthetic RTAs Synthetic RTAs are engineered molecules that mimic natural antioxidants, offering enhanced stability, potency, and bioavailability to scavenge radicals, prevent lipid peroxidation, and inhibit ferroptosis, with potential therapeutic applications in oxidative stress-related diseases like neurodegeneration and iron overload (Scarpellini et al., 2023b

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Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: evidence of ferroptosis