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De novo structure modeling for structure determination To predict the 3D model of human SRD5A2, similar to trRosetta 54 , we used a de novo approach from a predicted distance/orientation matrix, which was derived from a variety of multiple sequence alignments, using three sequence databases, UniClust30 (UC) 55 , UniRef90 (UR) 56 , and NR 57 , and then fused by implementing a deep residual network with a strip pooling module 58 to effectively capture long-range relationship of residual pairs