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Human placental extract ameliorates methotrexate-induced nephrotoxicity in albino rats: ultrastructural, biochemical and biophysical studies | Scientific Reports

Curcumin exerts multi‐targeted neuroprotective actions, ranging from blocking the aggregation of toxic α‐synuclein protein to activating pro‐survival signaling pathways (e.g., PI3K/Akt and BDNF pathways) [48, 67]

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NAD+ is a direct substrate replenishing cellular pools (low oral bioavailability), whereas 5-Amino-1MQ is an NNMT enzyme inhibitor protecting existing NAD+ from degradation