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Adding complextity to BBB-microglia interaction, a study by Krasnow et al., revealed that murine brain microvascular endothelial cells exposed to IL-1β before co-cultured with microglia, amplifies inflammatory gene expression in microglia, as compared to IL-1β exposure of isolated microglia (Krasnow et al., 2017)

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It was added to the Prohibited List in 2022 as a non-approved substance, reflecting its transition from an obscure research compound to a significant "substance of interest" in professional athletics