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Acyclic amino acids (Figure 2) The compounds within this series, which also includes l-Glu and l-Cys 2 , (i) represent some of the most straight forward structural mimics of the endogenous substrates

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In addition, higher levels of ROS have been shown to activate death receptors via downregulation of the FLIP—a protein that regulates apoptosis and functions as a key link between cell death and survival pathways (Wang et al